Protein name:
Axin-2 ;
Alternative:
Axis inhibition protein 2 ;Axin-like protein (Axil) ;Conductin ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin. Interacts with SMAD7 and RNF111 (By similarity). Interacts with ANKRD6.
Function:
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MSSAVLVTLL | PDPSSSFRED | APRPPVPGEE | GETPPCQPSV | GKVQSTKPMP |
100:
VSSNARRNED | GLGEPEGRAS | PDSPLTRWTK | SLHSLLGDQD | GAYLFRTFLE |
150:
REKCVDTLDF | WFACNGFRQM | NLKDTKTLRV | AKAIYKRYIE | NNSVVSKQLK |
200:
PATKTYIRDG | IKKQQIGSVM | FDQAQTEIQA | VMEENAYQVF | LTSDIYLEYV |
250:
RSGGENTAYM | SNGGLGSLKV | LCGYLPTLNE | EEEWTCADLK | CKLSPTVVGL |
300:
SSKTLRATAS | VRSTETAENG | FRSFKRSDPV | NPYHVGSGYV | FAPATSANDS |
350:
ELSSDALTDD | SMSMTDSSVD | GVPPYRMGSK | KQLQREMHRS | VKANGQVSLP |
400:
HFPRTHRLPK | EMTPVEPAAF | AAELISRLEK | LKLELESRHS | LEERLQQIRE |
450:
DEEKEGSEQA | LSSRDGAPVQ | HPLALLPSGS | YEEDPQTILD | DHLSRVLKTP |
500:
GCQSPGVGRY | SPRSRSPDHH | HQHHHHQQCH | TLLPTGGKLP | PVAACPLLGG |
550:
KSFLTKQTTK | HVHHHYIHHH | AVPKTKEEIE | AEATQRVRCL | CPGGTDYYCY |
600:
SKCKSHPKAP | EPLPGEQFCG | SRGGTLPKRN | AKGTEPGLAL | SARDGGMSSA |
650:
AGAPQLPGEE | GDRSQDVWQW | MLESERQSKS | KPHSAQSIRK | SYPLESACAA |
700:
PGERVSRHHL | LGASGHSRSV | ARAHPFTQDP | AMPPLTPPNT | LAQLEEACRR |
750:
LAEVSKPQKQ | RCCVASQQRD | RNHSAAGQAG | ASPFANPSLA | PEDHKEPKKL |
800:
ASVHALQASE | LVVTYFFCGE | EIPYRRMLKA | QSLTLGHFKE | QLSKKGNYRY |
840:
YFKKASDEFA | CGAVFEEIWD | DETVLPMYEG | RILGKVERID |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Axin-2
ELISA Kit for Mouse Axin-2
ELISA Kit for Mouse Axin-2
CLIA Kit for Mouse Axin-2
CLIA Kit for Mouse Axin-2
CLIA Kit for Mouse Axin-2
Polyclonal Antibody for Mouse Axin-2
Polyclonal Antibody for Mouse Axin-2
Polyclonal Antibody for Mouse Axin-2
Monoclonal Antibody for Mouse Axin-2
Monoclonal Antibody for Mouse Axin-2
Monoclonal Antibody for Mouse Axin-2
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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Linearity
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References
1.
"Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta."
Behrens J.
,
Jerchow B.-A.
,
Wuertele M.
,
Grimm J.
,
Asbrand C.
,
Wirtz R.
,
Kuehl M.
,
Wedlich D.
,
Birchmeier W.
Science280:596-599(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Properties of mouse Axin2 and human AXIN2: chromosomal location, expression pattern, interaction with Axin and effects on embryonic axis formation."
Zhang T.
,
Fagotto F.
,
Hsu W.
,
Zeng L.
,
Gilbert D.
,
Copeland N.G.
,
Jenkins N.A.
,
Warburton D.
,
Costantini F.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ANKRD6